Chemistry Department, Payame Noor University, 19395-4697, Tehran, I. R. of IRAN
10.7508/jns.2012.04.011
Abstract
Linear–dendrite copolymers containing hyper branched poly(citric acid) and linear poly(ethylene glycol) blocks PCA–PEG–PCA are promising nonmaterial to use in nanomedicine. To investigate their potential application in biological systems (especially for drug carries) ONIOM2 calculations were applied to study the nature of particular interactions between drug and the polymeric nanoparticles. Binding energy (BE) and interaction energy (IE) analysis of these complexes allowed the fundamental features of the drug- the Linear– dendritic copolymers interactions to be assessed based on ONIOM method. The results show that they have weak interaction and these complexes have relatively low stability and so PCA-PEG-PCA copolymers can use to as drug delivery.
Oftadeh, M., Madadi Mahani, N., & Bahjatmanesh Ardakani, R. (2012). The Investigation of a Linear-Dendrite Copolymeric Nanoparticles As Drug Carriers: ONIOM Study. Journal of Nanostructures, 2(4), 485-488. doi: 10.7508/jns.2012.04.011
MLA
M. Oftadeh; N. Madadi Mahani; R. Bahjatmanesh Ardakani. "The Investigation of a Linear-Dendrite Copolymeric Nanoparticles As Drug Carriers: ONIOM Study". Journal of Nanostructures, 2, 4, 2012, 485-488. doi: 10.7508/jns.2012.04.011
HARVARD
Oftadeh, M., Madadi Mahani, N., Bahjatmanesh Ardakani, R. (2012). 'The Investigation of a Linear-Dendrite Copolymeric Nanoparticles As Drug Carriers: ONIOM Study', Journal of Nanostructures, 2(4), pp. 485-488. doi: 10.7508/jns.2012.04.011
VANCOUVER
Oftadeh, M., Madadi Mahani, N., Bahjatmanesh Ardakani, R. The Investigation of a Linear-Dendrite Copolymeric Nanoparticles As Drug Carriers: ONIOM Study. Journal of Nanostructures, 2012; 2(4): 485-488. doi: 10.7508/jns.2012.04.011
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