Nano Silica Phosphoric Acid: An Efficient Catalyst for the One- Pot Synthesis of 1, 2, 4, 5-Tetrasubstituted Imidazoles

Document Type : Research Paper


1 Deprtment of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I. R. Iran.

2 Department of Chemistry, College of Science, Yazd University, I. R. Iran .



Two  simple  protocols  for  the  synthesis  of  1,  2,  4,  5-   tetrasubstitutedimidazoles  using  nano-SPA  as  a  reusable,  eco-   friendly,  inexpensive,  and  efficient  catalyst  are  reported.  Short   reaction  times,  high  yields,  scale-up  and  easy  workup  are  the   advantages of these protocols.