One-pot synthesis of bis-spiro piperidines using nanocellulose/BF3/Fe3O4 as a natural based catalyst

Articles in Press

Document Type : Research Paper

Authors

1 Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R.Iran

2 Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R.Iran.

3 Department of Organic Chemistry, College of Science, Yazd University, Yazd, I.R.Iran

Abstract

Recently, multi-component reactions (MCRs) have been purposeful and they have become a serious area of research in medicinal and chemical science. A highly impressive one-pot multicomponent synthesis of bis-spiro piperidine derivatives has been reported by performing the reaction of formaldehyde, aromatic aniline and dimedone (in ratio of 3:1:2) compounds. This reaction was performed in the presence of nanocellulose/BF3/Fe3O4 as Lewis acid and heterogeneous catalyst in ethanol at room temperature. Nano-cellulose/BF3/Fe3O4 as a Lewis acid catalyst has been synthesized and characterized with Field Emission Scanning Electron Microscopy (FE-SEM), Transmission Electron Microscopy (TEM), Fourier Transform Infrared (FT-IR), Thermal Gravimetry Analysis (TGA), X-ray Diffraction (XRD), X-ray fluorescence (XRF) and (Vibrating sample Magnetometry Measurements (VSM) analysis. The advantages of this protocol are low reaction time, high yield of products, simplicity of operation and reusability of catalyst. The structure of the obtained bis-spiro piperidine derivatives were studied by FT-IR and Nuclear Magnetic Resonance (1H NMR) spectroscopy.

Keywords

Journal of Nanostructures

Articles in Press, Accepted Manuscript
Available Online from 06 May 2025

Files

Share

How to cite

Statistics