Development of Lipid Nanoparticles for Targeted Drug Delivery in Brain Tissue

Articles in Press

Document Type : Research Paper

Authors

1 Department of Pharmacy, Kut University College, Kut 52001, Wasit, Iraq

2 DSc, Associate Professor of the Bukhara State Medical Institute Named After Abu Ali Ibn Sino, Uzbekistan

3 Department of Obstetrics and Gynecology No. 2, Faculty of Pediatrics, Samarkand State Medical University, Uzbekistan

4 Deparment of Pediatrics, Fergana Medical Institute of Public Health, Uzbekistan

5 Tashkent State Technical University, Uzbekistan

6 Department of Fruits and Vegetables, Urganch State University, Uzbekistan

Abstract

Targeted drug delivery to brain tissue remains a significant challenge in treating neurological disorders due to the restrictive nature of the blood-brain barrier (BBB). This study focuses on the development of lipid-based nanoparticles (LNPs) to enhance drug transport across the BBB and overcome its limitations. The LNPs were synthesized using an emulsion/solvent evaporation technique and surface-modified with specific ligands, such as transferrin receptor-targeting peptides or apolipoprotein E, to facilitate BBB penetration. Physicochemical properties, including particle size, surface charge, and stability, were analyzed via transmission electron microscopy (TEM) and dynamic light scattering (DLS). In vitro evaluations using cerebral endothelial cell models demonstrated that ligand-functionalized LNPs exhibited enhanced cellular uptake, achieving a 40% increase in transcytosis efficiency compared to unmodified counterparts. In vivo studies in animal models confirmed targeted drug distribution in brain tissue and minimized off-target accumulation in peripheral organs. The results indicate that these nanocarriers possess favorable biocompatibility with no significant cytotoxicity. Overall, surface-engineered LNPs represent a promising strategy for treating neurological diseases such as Alzheimer’s, Parkinson’s, and glioblastoma. However, challenges including scalable manufacturing and long-term toxicity assessments require further investigation. This research advances the potential for personalized therapeutic interventions while mitigating systemic side effects associated with conventional drug delivery systems.

Keywords

Journal of Nanostructures

Articles in Press, Accepted Manuscript
Available Online from 01 May 2025

Files

Share

How to cite

Statistics