In supported palladium nanoparticles on PMO, the Suzuki C-C coupling reaction by L-serine-based Pd@L-serine-PMO as a reusable catalyst could be a research gap. In different reaction condition, this material could save its efficiency and stability for a longer duration. Such studies may provide insights into whether the catalyst can effectively be used in organic syntheses after several reactions and under various conditions. Additionally, information about the interaction between Pd Nanoparticles and the L-Serine-PMO framework could be beneficial for improving the reusability and catalytic efficiency of this catalyst in the Suzuki C-C coupling reaction. One notable advancement highlighted in this article is the utilization of a catalyst that, as per the study conducted, has not previously been employed in facilitating the Suzuki coupling process. This study produced nano Pd@L-Serine-PMO. Suzuki C-C coupling technique was employed to study the catalytic activity of a new and effective heterogeneous catalyst. Nano Pd@L-Serine-PMO was studied using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive spectroscopy (EDS), and thermal gravimetric analysis (TGA). Some of the desirable features of this reaction are the mild reaction conditions, use of green solvents, short reaction times, and proper efficiency. It was possible to filter out the solid Nano Catalyst and reuse it several times without any decrease in activity