Effects of Nano-silver synthesized by Cassia angustifolia leaf extract against dental caries fungi

This research was aimed to isolate fungi in the patients with dental caries, in the males and females, and to evaluate the antifungul activity of biogenic synthesized silver nanoparticles from Cassia angustifolia leaves aqueous extract against fungal infection. The results show that 55 swab samples of dental caries with fungi ranged in age from 10 to 50 years old, the infection is a higher rate in femals than males with rate (55)% and (45)% in males with age ranging from (20 to 40). The most common fungi isolated from dental caries are Aspergillus niger 41%, Aspergillus flavus 25%, Penicillium spp. 20 % and the lowest is Alternaria spp. is 12 %. The most important yeasts that appeared in dental caries are Candida albicans 50% and C.krusei 10% Candida is the major fungal pathogen of human causing a variety of afflictions ranging from superficial mucosal diseases to deep seated mycoses. Cassia angustifolia leaves aqueous were used for the green synthesis of Ag NPs with the results demonstrating the ability of Ag NPs produced by C.angustifolia in vitro to inhibit the growth of fungi at (pH 8)to decrease growth of fungi that are Aspergillus niger , A. flavus , Alternaria spp. and Penicillium spp.by percentage(80 ,42 ,77 ,7)% respectively in the concentration 100 µg /ml respectively that is broad applications in decrease pathogenic fungi and therapeutic manufacturing.