Antibacterial activity of calcium carbonate Nanoparticles with Indole against persister Pseudomonas aeruginosa

Articles in Press

Document Type : Research Paper

Authors

1 Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq

2 Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq

Abstract

Researchers are working to develop a new class of antimicrobial agents due to the high prevalence of microbial diseases and their multidrug resistance properties. The use of indole with nanoparticles as new antimicrobial agent formulations is a modern and innovative approach to drug development. Current study demonstrates the antimicrobial efficacy of indole with calcium carbonate Nanoparticles (caco3-NPs) against gram negative, opportunistic bacterial infection, Pseudomonas aeruginosa. Caco3-NPs alone show a significant antibacterial activity, with inhibition zones range from 8 to 17 mm at concentration 10.000 μg /ml. While the indole alone too with inhibition zones range from 27 to 35 mm. The minimum inhibitory concentration(MIC) of caco3-NPs showed a strong antibacterial activity 312.5 μg /ml. At the same time, the MIC of Indole was 156.2 μg /ml. When combined Indole with caco3-NPs, they show increased inhibition rate of growth and biofilm formation by persister cell of P. aeruginosa. Caco3-NPs greatly aided biofilm inhibition with Indole about 63.32 percent at 10 mg /ml concentration. As a result, caco3-NPs and Indole significantly impacted P. aeruginosa persister cells' biofilms formation.

Keywords

Journal of Nanostructures

Articles in Press, Accepted Manuscript
Available Online from 29 February 2024

Files

Share

How to cite

Statistics