1
Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq
2
Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq
Abstract
Researchers are working to develop a new class of antimicrobial agents due to the high prevalence of microbial diseases and their multidrug resistance properties. The use of indole with nanoparticles as new antimicrobial agent formulations is a modern and innovative approach to drug development. Current study demonstrates the antimicrobial efficacy of indole with calcium carbonate Nanoparticles (caco3-NPs) against gram negative, opportunistic bacterial infection, Pseudomonas aeruginosa. Caco3-NPs alone show a significant antibacterial activity, with inhibition zones range from 8 to 17 mm at concentration 10.000 μg /ml. While the indole alone too with inhibition zones range from 27 to 35 mm. The minimum inhibitory concentration(MIC) of caco3-NPs showed a strong antibacterial activity 312.5 μg /ml. At the same time, the MIC of Indole was 156.2 μg /ml. When combined Indole with caco3-NPs, they show increased inhibition rate of growth and biofilm formation by persister cell of P. aeruginosa. Caco3-NPs greatly aided biofilm inhibition with Indole about 63.32 percent at 10 mg /ml concentration. As a result, caco3-NPs and Indole significantly impacted P. aeruginosa persister cells' biofilms formation.
M.Ahmed, A., Al Marjani, M. F., & Mahdi Rheima, A. (2024). Antibacterial activity of calcium carbonate Nanoparticles with Indole against persister Pseudomonas aeruginosa. Journal of Nanostructures, (), -.
MLA
Alaa M.Ahmed; Mohammed F. Al Marjani; Ahmed Mahdi Rheima. "Antibacterial activity of calcium carbonate Nanoparticles with Indole against persister Pseudomonas aeruginosa", Journal of Nanostructures, , , 2024, -.
HARVARD
M.Ahmed, A., Al Marjani, M. F., Mahdi Rheima, A. (2024). 'Antibacterial activity of calcium carbonate Nanoparticles with Indole against persister Pseudomonas aeruginosa', Journal of Nanostructures, (), pp. -.
VANCOUVER
M.Ahmed, A., Al Marjani, M. F., Mahdi Rheima, A. Antibacterial activity of calcium carbonate Nanoparticles with Indole against persister Pseudomonas aeruginosa. Journal of Nanostructures, 2024; (): -.