Synthesis of nanocomposite drug structure containing chitosan/ gelatin and its application in diclofenac release control

Document Type : Research Paper

Authors

Department of Chemistry, Faculty of Science, Arak University, Arak 38156‑8‑8349, Iran

10.22052/jns.2024.254230.3181

Abstract

In the drug delivery system, the goal is to achieve a sustained release formulation that improves the effectiveness of drugs in certain tissues by releasing the drug for a longer period of time. On the other hand, biodegradable polymers are a suitable choice in this field. There are several properties that make biodegradable polymers suitable as carriers for drug delivery: predictable biodegradation behavior, biocompatibility, ease of fabrication, availability. Nowadays, nanoparticles have received much attention due to their wide applications in various fields of biology and medicine. Nanomaterials have great potential to increase the efficiency of pharmaceutical systems in drug delivery. In this research, gelatin and chitosan have been used as a polymer coating, which leads to the stability of barium hexaferrite nanoparticles in the pharmaceutical structure and prevents the accumulation of substances. Also, glycerin was used to improve the flexibility of drug structure containing diclofenac sodium. When nanoparticles are dispersed in a polymer substrate or coated with polymers, the improvement in performance of drug release systems can be achieved. For this purpose, in the laboratory, solutions with the same pH as blood in the human body were prepared and the effect of different parameters on the amount and manner of diclofenac release were investigated. Also, analyzes such as FTIR, XRD, SEM and VSM were used to characterize the nanostructures.

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