Preparation, spectral characterization, antimicrobial and cytotoxic Studies, of some transition metal nanocomplexes of a novel azo derivative formed from 2-amino -5- methylthiazol

The present investigation delineates the synthetic procedure employed for the production of 2-[2’-(5-methylthiazolyl)azo]-5,6-Dimethyl benzoimidazole (L1) and its corresponding silver(I) complex (C1) as well as gold(III) complex (C2). The ligand and the complexes underwent comprehensive characterization using a range of analytical techniques including FT-IR spectroscopy, nuclear magnetic resonance 1H-NMR spectroscopy, 13C-NMR spectroscopy, mass spectrometry, Elemental Analysis (CHNS), molar conductivity measurements, X-Ray diffraction analysis, field emission scanning electron microscopy (FE-SEM), and magnetic susceptibility measurements. The antibacterial and antifungal properties of these compounds were assessed, revealing that the synthesized compounds demonstrated superior efficacy against bacteria in comparison to conventional antibacterial medications. Nevertheless, their efficacy against fungal pathogens was observed to be comparatively diminished in comparison to conventional antifungal medications. Based on the findings from molecular docking investigations, the synthesized compounds were evaluated for their binding affinity towards the kinase domain of human DDR1 in conjunction with the pancreatic cancer-associated protein. Furthermore, the L1 compound and C1 compound were subjected to evaluation in terms of their anti-cancer efficacy against a specific pancreatic carcinoma cell line (TP-53) utilizing the MTT assay. The experimental results have revealed that the examined compounds exhibit noteworthy anti-cancer properties, thereby implying their prospective utilization as auspicious contenders for subsequent advancement as anti-neoplastic agents.