Novel Thiazolyl Azo Dyes: Elucidating the Design, Synthesis, Spectral Characterization, Cytotoxicity, and Antibacterial Potential of its Co(III), Ni(II), and Cu(II) NanoComplexes

Articles in Press

Document Type : Research Paper

Authors

Department of Chemistry, College of Science, University Al- Muthanna, Iraq

Abstract

2-[2-(5-Methylethiazolyl) azo] and the combination of its cobalt(III), nickel(II), and copper(II) complexes yields the new bidentate azo dye ligand 5,6-dimethylbenzimidazole (5-MeTADMBI). The suggested structures were found by using atomic absorption spectroscopy, molar conductivity, magnetic susceptibility, nuclear magnetic resonance (1H NMR) and 13C NMR, Fourier transforms infrared (FTIR), ultraviolet-visible (UV-Vis), mass spectrometry, X-ray diffraction (XRD), thermogravimetric analysis (TGA/DTG), and scanning electron microscope field emission (FE-SEM). All complexes have been given geometry suggestions according to analytical and spectroscopic data with cobalt(III), nickel(II), and copper(II) ions, the 5-MeTADMBI ligand takes an octahedral shape via N, N donors and behaves as a bidentate. The biological testing of the synthesized compounds against Escherichia coli, Staphylococcus aureus, Klebsiella and candida. revealed increased antibacterial activity. Their testing revealed that the metal complexes are superior against a variety of bacterial and fungal species. Finally, based on IC50, most of the compounds exhibited potent anticancer activity towards both the A549 human lung cancer cell line and the normal human lung fibroblast HdFn cell line.

Keywords

Journal of Nanostructures

Articles in Press, Accepted Manuscript
Available Online from 03 February 2024

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