Document Type : Research Paper
Poff. Ph.D. Pharm. & toxic, MSc Physiol.; College of Veterinary Medicine, University of Baghdad
The satisfactory endpoint of creation Nanoparticles hemosome carrying Zinc phosphide manifested by the size of Nano hemosome loaded Zinc phosphide ranged (55.83-111.69 nm) as multi-lamellar multi-vesicle shape. The entrapment amounts and efficiency have been achieved 86.84±3.55 % and 80.17±5.03 % of Zinc phosphide respectively. The absorbance curve displayed a higher peak set in (λ peaks) 343 nm and 439 nm. The challenge of hemosomal loaded Zinc phosphide was appeared tonicity tolerance to Osmo-changes ranged at 6-9 % of media and the pH changes stability was cited within 4-7 pH of the incubated media.
Results showed the mice were more potent and susceptible to Nano-Heamosomal encapsulated Zinc phosphide than Ordinary Zinc Phosphide. The LDs with treated mice were The LD20, 50, and 95 of Nano heamosome Zn3P2 lower value 7243, 16959.51 and 89430.27 µg/kg/BW as compared with ordinary Zn3P2 13767.6, 28265.391, and 115291.4 µg/kg. Bw. The sub-acute LD20, 50, and 95 of Nano heamosome Zn3P2 lower value 2421.9, 3758.9, and 8875.7 µg/kg/BW as compared with Ordinary Zn3P2 (4180.12, 6591.32 and 16030.45 µg/kg. Bw).
The LCs of dosed Zn3P2; LD50 dose in mice, the LC20, 50, and 95 of Nano-heamosome Zn3P2 lower value 3.85, 12.80, and 139.09 ppm as compared with ordinary Zn3P2 4.4, 23.90, and 650.15 ppm. The concentration of delayed lethal response to sub-acute toxicity LCs of dosed Zn3P2 (LD50 dose) in mice was an exhibit in two forms of rodenticides pharmaceutics.