Rodenticide Efficiency of Oral Dosed Nanoparticles Hemosome Loaded Zinc phosphide in Mice

The satisfactory endpoint of creation Nanoparticles hemosome carrying Zinc phosphide manifested by the size of Nano hemosome loaded Zinc phosphide ranged (55.83-111.69 nm) as multi-lamellar multi-vesicle shape. The entrapment amounts and efficiency have been achieved 86.84±3.55 % and 80.17±5.03 % of Zinc phosphide respectively. The absorbance curve displayed a higher peak set in (λ peaks) 343 nm and 439 nm. The challenge of hemosomal loaded Zinc phosphide was appeared tonicity tolerance to Osmo-changes ranged at 6-9 % of media and the pH changes stability was cited within 4-7 pH of the incubated media.
Results showed the mice were more potent and susceptible to Nano-Heamosomal encapsulated Zinc phosphide than Ordinary Zinc Phosphide. The LDs with treated mice were The LD20, 50, and 95 of Nano heamosome Zn3P2 lower value 7243, 16959.51 and 89430.27 µg/kg/BW as compared with ordinary Zn3P2 13767.6, 28265.391, and 115291.4 µg/kg. Bw. The sub-acute LD20, 50, and 95 of Nano heamosome Zn3P2 lower value 2421.9, 3758.9, and 8875.7 µg/kg/BW as compared with Ordinary Zn3P2 (4180.12, 6591.32 and 16030.45 µg/kg. Bw).
The LCs of dosed Zn3P2; LD50 dose in mice, the LC20, 50, and 95 of Nano-heamosome Zn3P2 lower value 3.85, 12.80, and 139.09 ppm as compared with ordinary Zn3P2 4.4, 23.90, and 650.15 ppm. The concentration of delayed lethal response to sub-acute toxicity LCs of dosed Zn3P2 (LD50 dose) in mice was an exhibit in two forms of rodenticides pharmaceutics.