Background: Recently, lipid nanoparticles has showed excellent properties that encourage researchers to use them in different fields such as agriculture, industry, medicine and in drugs as a nanocarriers to improve the delivery and the absorption of the vitamins, and drugs that are taken orally and/or parenterally. Objective: The current research was carried out to o develop a nano lipid carrier for curcumin to enhance its poor solubility and bioavailability to increase the pharmacological action. Materials and Methods: The drug carrier was synthesized as NLC using hot high pressure homogenization method (HHPH) and was obtained from glyceryl monostearate(GMS) as solid lipid and oleic acid as liquid lipid, in total, four different compositions of the drug carrier (curcumin nano lipid) were synthesized using different solid :liquid ratios (1:1,1:2,2:1 and 1:3) and characterized using different physic-chemical techniques such as FTIR, DSC, distribution of particles size, zeta potential and TEM. The in-vivo studies were conducted to test the enhanced solubility and bioavailability of curcumin-NLC formulation. Results: The nano lipid carrier system were synthesized using GMS and oleic acid as solid and liquid lipid respectively. Moreover, Tween 80 and Poloxamer 188 were utilized as surfactants.