Document Type : Research Paper
School of Pharmacy, JSC &quot; S.D. Asfendiyarov Kazakh National Medical University &quot;, Almaty, Kazakhstan
School of Pharmacy, JSC " S.D. Asfendiyarov Kazakh National Medical University ", Almaty, Kazakhstan
Kazakh Scientific Research Institute of Animal Husbandry and Forage Production”, Almaty, Kazakhstan,
The purpose of this study is to combine the unique properties of nanoparticles with the antimicrobial activity of essential oil in order to obtain a nanobiosystem that could be pelliculised on the surface of catheter pieces, in order to obtain an improved resistance to microbial colonization and biofilm development. The present study describes the phytochemical profile and antimicrobial activity of Zea Mays L. essential oil. The sample of essential oil were obtained from the corn germ by subcritical CO2 extraction and analyzed by GC/FID. From the 63 compounds representing 99.99% of the oils, most of the isolated components are Cyclohexanone, 5-methyl-2-(1-methylethylidene) - 20.91%, Cyclohexanone, 5-methyl-2-(1-methylethyl) – 13.24 %, Bicyclo [4.1.0]heptan-3-ol, 4,7,7-trimethyl – 9,51 %, Phenol, 2-methyl-5-(1-methylethyl)- 6,51%, thymol - 3.99%, l-Menthone – 3,03%, squalene - 2.85%, 2(4H)-Benzofuranone, 5,6,7,7a-tetrahydro-3,6-dimethyl- 2,40%, Benzofuran, 2,3-dihydro- 2,13%, Terrein -2,09%, Phytol – 2,02%, 4,8,12,16-Tetramethylheptadecan-4-olide – 2,01% and endo-borneol - 1.22%. The total amount of 12 components is 71.91%. Furthermore, antimicrobial activity of the oil was evaluated using agar diffusion and broth microdilution methods. The antimicrobial test results showed that the oils had a great potential antimicrobial activity against against strains of S. aureus and the spore-forming test strain B. subtillis and E. coli.