Synthesis of Mesoporous Silica and Modified as a Drug Delivery System of Ibuprofen

Document Type : Research Paper

Authors

1 Babol University of Medical Sciences, pramedicine Faculty, Anesthesiology and Operation Department, Babol, Iran

2 Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

10.7508/jns.2016.01.014

Abstract

In this work we synthesized of mesoporous silica nanoparticles and functionalized with 3-aminopropyltriethoxysilane to improve the loading and release of ibuprofen bonded to 3-aminopropyltriethoxysilane. sample were characterized by Fourier transform infrared spectroscopy, Scanning electron microscopy , X-ray diffraction, and ultraviolet-visible. the Fourier transform infrared spectroscopy result demonstrate that organic group were successfully functionalized onto mesoporous silica nanoparticles. Then, we investigate of the adsorption and release of ibuprofen as a drug delivery system in simulated body fluid. The result demonstrates that high adsorption capacity for drug with functionalized sample and slower drug release rate was achieved.

Keywords

Journal of Nanostructures
Volume 6, Issue 1 - Serial Number 1
January 2016
Pages 86-89

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