University of Kashan Journal of Nanostructures 2251-7871 15 2 2025 04 01 Effect of Cucurbita Pepo Nanoshells on Some Antibiotic-Resistant Pathogenic Microorganisms 732 739 114973 10.22052/JNS.2025.02.031 EN Adil Turki Al-musawi Market Research and Consumer Protection Center, University of Baghdad, Iraq Aliaa Saadoon Abdul- Razaq Al-Faraji Market Research and Consumer Protection Center, University of Baghdad, Iraq Sudad Jasim Mohammed Market Research and Consumer Protection Center, University of Baghdad, Iraq Journal Article 2025 01 28 The bio-based approach to synthesizing nanoparticles has been one of most interesting trends in nano science over the past decade. This is due to its environmentally friendly and green chemistry method, which is safe to use and free of chemical pollutants for biological applications. Study’s results demonstrated the effectiveness of using zucchini peel nanoparticles in combination with silver nanoparticles as an alternative to inhibitory materials for drug-resistant microorganisms. The results of the FTIR analysis showed that AgNO3 had four strong bands at (3211, 1632, 1520, 1390, and 1239) cm-1 while AgNPS had seven strong bands at (3211, 2940, 1632, 1523, 1395, 1241 and 1050) cm-1. XRD analysis revealed four different diffraction peaks for AgNO3 (32.77°, 38.11°, 49.66°and 67.54°), while AgNPS showed five strong diffraction peaks (32.77°, 56.13°, 58.22°, 67.54º and 75.88º). In terms of inhibiting Pseudomonas aeruginosa, AgNPS had the highest inhibition zone of 14 mm at a concentration of 10 mg/ml, the inhibition zone increased to 25 mm when the concentration was increased to 20 mg/ml. on the other hand AgNO3 had 9 mm inhibition zone at a concentration of 10 mg/ml, which increased to 16 mm at concentration of 20 mg/ml. Nanotechnology is providing alternatives to treatments that have harmful effects on the body due to their imprecise delivery methods to targeted diseased cells, such as cancer chemotherapy. Researchers have utilized nanotechnology to attach special RNA with a small diameter of about 10 nanometers to nanoparticles filled with chemotherapy drugs to mitigate the pain and harmful effects associated with chemotherapy. https://jns.kashanu.ac.ir/article_114973_8b48cf461cf46f1e5dbd7ad3da56afa1.pdf