University of Kashan Journal of Nanostructures 2251-7871 14 1 2024 01 01 Cu (II) Salen Complex@KCC-1: An Effective and Beneficial Catalyst for the Preparation of 1,4-Dihydropyridine Derivatives via Hantzsch Reaction 156 167 114555 10.22052/JNS.2024.01.016 EN Atefeh Zeinali Department of organic chemistry, Faculty of chemistry, university of Kashan, Kashan, I.R. Iran Ali Allahresani Department of Chemistry, Faculty of Science, University of Birjand, Birjand, Iran Mohammad Ali Nasseri Department of Chemistry, Faculty of Science, University of Birjand, Birjand, Iran Abdulhamid Dehghani Department of organic chemistry, Faculty of chemistry, university of Kashan, Kashan, I.R. Iran Journal Article 2023 10 10 Cu (II) Salen complex@KCC-1 has been synthesized and characterized via XRD, FT-IR, SEM, TEM, BET, and EDX analysis. An effective and useful Hantzsch preparation of a variety of 1,4-dihydropyridine (1,4-DHP) from a β-dicarbonyl compound, benzaldehyde (BzH), and ammonium acetate with Cu (II) Salen complex@KCC-1 in the H2O/EtOH (with a ratio of 1:1) as the solvent and 65ºC were obtained. The synthesized catalyst was determined to be a useful heterogeneous catalyst for preparing 1,4-DHP. Short reaction times, high yields of products, reusability of catalyst, ease of catalyst separation, versatility, and simple workup procedure are the main advantages of the presented method for the synthesis of 1,4-dihydropyridine derivatives. Moreover, the catalyst was stable in the reaction system and could be easily recovered from the reaction media and reused for 5 runs without significant loss in catalytic activity. In addition, the results of hot filtration studies show the lack of copper leaching from the catalyst surface. https://jns.kashanu.ac.ir/article_114555_949fce6da2fbbf88e56819a41d66d5bb.pdf