University of Kashan Journal of Nanostructures 2251-7871 14 1 2024 01 01 The Effect of Copper Oxide Nanoparticles on Hepatic and Renal Toxicity in Domestic Rabbits 150 155 114544 10.22052/JNS.2024.01.015 EN Salamat Yegeubayeva Almaty Technological University, Almaty, Republic of Kazakhstan Allanazarova Feruza Karimberdievna Nukus State Pedagogical Institute named after Ajiniyaz, Uzbekistan Amantai Kunakbayev Department of Anatomy with Physiology Courses, Kazakh-Russian Medical University, Almaty, Kazakhstan Rakhimov Sherzod Department of Technology, University of Geological Sciences, Uzbekistan Bobomurodova Munojat University of Geological Sciences, Uzbekistan Sherquziyeva Guzal Faxritdinovna Department of Environmental Hygiene, Tashkent Medical Academy, Uzbekistan Bakhtiyor Omonov Department of Mechanical and Aerospace engineering, Turin Polytechnic University in Tashkent, Uzbekistan Bobojonov Otabek Khakimboy Ugli Department of Fruits and Vegetables, Urganch State University, Uzbekistan Mirzakarimova Makhliyokhon Andijan State Institute of Foreign Languages, Uzbekistan Khayitmuradov Anvarjon Termez State University, Termez, Uzbekistan I.B. Sapaev Tashkent Institute of Irrigation and Agricultural Mechanization Engineers, National Research University, Tashkent, Uzbekistan University of Tashkent for Applied Sciences, Uzbekistan Western Caspian University, Scientific researcher, Baku, Azerbaijan Mirzayeva Mutabar Azamovna Faculty of Agriculture, Fergana State University, Uzbekistan Komilov Rustamjon Makhamadovich Faculty of Agriculture, Fergana State University, Uzbekistan Journal Article 2023 10 08 The production and use of engineered nanomaterials in various industries, especially the food industry, and its influence in food products have caused concerns in the field of health. The aim of this study is to investigate the toxicity level and evaluate the effects of copper oxide nanoparticles (CuO NPs) on internal tissues. For this purpose, the effect of different doses of copper oxide nanoparticles in the kidney tissue of rabbits was evaluated. In this experimental study, 48 domestic rabbits were randomly divided into 4 groups of 12 cases. One group was considered as the control group, and three groups of rabbits were injected with doses of 5, 15, and 25 mg of oxide nanoparticles in 3 times a day for 15 days. Then, the biochemical factors (Blood Urea Nitrogen), BUN, Uric Acid (UA) and Creatinine (Cr) were measured in the kidney. The kidney tissue was examined in three stages of blood collection (one day, 8 days and 15 days after the treatment). Also, after 15 days, the animals were isolated and the kidney tissue sections were prepared and studied with hematoxylin-eosin staining. The activity of kidney biochemical factors did not show any significant change between the different groups in the blood collection stages, so that in the first blood collection, there was a significant increase in all three treatment groups compared to the control group. The control showed the greatest changes after 15 days (the third blood draw). There was no significant statistical difference in the weight of the rabbits between the different groups. Histological studies showed multiple tissue damage in the treatment groups, including hyperemia, degeneration of hepatocytes, hyperplasia and inflammation. Microscopic results also showed that the most changes in hepatocyte cells, central lobular vein and sinusoidal space and cause tissue damages. https://jns.kashanu.ac.ir/article_114544_bb20c3c6fce1578c9c2493caf38baab8.pdf