University of Kashan Journal of Nanostructures 2251-7871 14 2 2024 04 01 Novel Thiazolyl Azo Dyes: Elucidating the Design, Synthesis, Spectral Characterization, Cytotoxicity, and Antibacterial Potential of its Co(III), Ni(II), and Cu(II) NanoComplexes 392 410 114189 10.22052/JNS.2024.02.004 EN Suha Hassan Majhool Department of Chemistry, College of Science, University Al- Muthanna, Iraq Azal Shakir Waheeb Department of Chemistry, College of Science, University Al- Muthanna, Iraq Masar Ali Awad Department of Chemistry, College of Science, University Al- Muthanna, Iraq Journal Article 2024 01 22 2-[2-(5<strong>-</strong>Methylethiazolyl) azo] and the combination of its cobalt(III), nickel(II), and copper(II) complexes yields the new bidentate azo dye ligand 5,6-dimethylbenzimidazole (5-MeTADMBI). The suggested structures were found by using atomic absorption spectroscopy, molar conductivity, magnetic susceptibility, nuclear magnetic resonance (¹H NMR) and ¹³C NMR, Fourier transforms infrared (FTIR), ultraviolet-visible (UV-Vis), mass spectrometry, X-ray diffraction (XRD), thermogravimetric analysis (TGA/DTG), and scanning electron microscope field emission (FE-SEM). All complexes have been given geometry suggestions according to analytical and spectroscopic data with cobalt(III), nickel(II), and copper(II) ions, the 5-MeTADMBI ligand takes an octahedral shape via N, N donors and behaves as a bidentate. The biological testing of the synthesized compounds against Escherichia coli, Staphylococcus aureus, Klebsiella and candida. revealed increased antibacterial activity. Their testing revealed that the metal complexes are superior against a variety of bacterial and fungal species. Finally, based on IC50, most of the compounds exhibited potent anticancer activity towards both the A549 human lung cancer cell line and the normal human lung fibroblast HdFn cell line. https://jns.kashanu.ac.ir/article_114189_4a4876d1ec28058d64e87cc6547dcc9e.pdf