University of Kashan Journal of Nanostructures 2251-7871 12 3 2022 07 01 Inhibitory Effect of ZrO2NPs on Candida Albicans in Heat-Cured Acrylic-Based Soft Lining Material 771 773 112822 10.22052/JNS.2022.03.030 EN Amir Fadhil Al-Tu’ma Ahl Al Bayt University, College of MLT, Kerbala, Iraq Zeena Dhubyan Mohammed Zaki Department of Dentistry, AlNoor University College, Bartella, Iraq Randa Ahmed College of Medical Technology/ Al-Farahidi University, Iraq Sarah Kamil Abbood Medical laboratory Techniques Department, AL-Mustaqbal University College, Iraq Ali Abdul Kadhim Ruhaima AL-Nisour University College, Baghdad, Iraq Zainab Jamal Hamoodah Mazaya University College, Iraq Ahmed S. Abed Department of Prosthetic Dental Technology, Hilla University college, Babylon, Iraq Irina V. Pavlova Belgorod State National Research University, 85, Pobedy St, Belgorod, 308015, Russian Federation Journal Article 2022 04 03 The most prevalent issue that can contribute to persistent mucosal inflammation is the development of microorganisms and fungi, particularly Candida Albicans (C. albicans), on soft denture lining material. The objective of the current study is to identify the inhibitory effect of Zirconium Oxide Nanoparticles (ZrO2NPs) on C. albicans in heat-cured acrylic-based soft lining material and the quantity of zirconium ions (Zr) released by the composite of soft liner and ZrO2NPs. Soft denture liners made of acrylic were given varied ratios of ZrO2NPs. According to the test that will be conducted, 200 samples were separated into two groups (experimental and control). The soft liner/ZrO2NPs composite’s antifungal activity was evaluated utilizing two techniques over three distinct time periods (disk-diffusion test and viable count of C. albicans). Atomic Absorption Spectroscopy (AAS) was used to measure the amount of Zr emitted in synthetic saliva over two separate time periods. The strength of the soft liner’s shear bond to the denture base material made of acrylic was evaluated using an Instron testing equipment. Compared to the control group, there was a highly significant drop in C. albicans colony forming units in the experimental groups (1.5% and 2% ZrO2NPs). Once ZrO2NPs were added to soft liners at a rate of 2%, the shear bonding strength’s mean value increased in a manner that was highly significant. As a result of this research, ZrO2NPs could be incorporated into acrylic-based soft denture lining materials to give them antifungal qualities, which lower the risk of developing denture-induced stomatitis. https://jns.kashanu.ac.ir/article_112822_0e4eeed44f8627afeb91dcbdcb4cbfb9.pdf