University of Kashan Journal of Nanostructures 2251-7871 11 3 2021 07 01 Preparation of Degeredable Polyprolactone Polymer (PCL)/Magnetic nanocomposite for Drug Delivery Systems Against Anticancer Compounds 456 469 111639 10.22052/JNS.2021.03.005 EN Nasrin Nikzamir Department of Nanochemistry, Faculty of Fundamental Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran Hossein Khojasteh Department of Chemistry, Faculty of Science, Soran University, P. O. Box 624, Soran, Kurdistan Regional Government, Iraq Mehrdad Nobakht Vakili Department of Biochemistry, Faculty of Fundamental Sciences, Kurdistan University, Sanandaj, Iran Chalak Azimi Department of chemistry, Faculty of science, Mahabad branch, Islamic Azad University Elahe Ghanbari Department of Physical Chemistry, Faculty of Fundamental Sciences,Payame Noor University of Urmia,Urmia, iran Journal Article 2021 05 16 Magnetic nanoparticles have been used primarily for medical advances, chemotherapy, and specialized tissue repair for targeted drug delivery. In this research, magnetic iron nanoparticles were first prepared and identified. Then, biodegradable copolymer of polypro-pylene capro-lactone-polyethylene glycol PCL-PEG1000-PCL was synthesized. Doxorubucin nanoparticles were prepared by using copolymer containing magnetic nanoparticles by solvent-evaporation method. VSM, FT-IR, UV-vis, 1H-NMR and SEM were used to determine the structural properties of copolymer nanoparticles. The synthesis of PCL-PEG1000-PCL triple-block copolymer and doxorubicin and iron nanoparticles encapsulation were confirmed by the mentioned characterization methods. The resulting nanoparticles have superparamagnetic properties and the drug encapsulation yield was about 95%. The effect of pH and heat on drug release curve was investigated.<br />The results showed that the copolymer synthesized is suitable for the encapsulation of doxorubicin and iron nanoparticles and can be effective as a carrier of novel nanostructures in the delivery of anticancer drugs. The results showed that due to the properties of magnetic nanoparticles and copolymers they can be used for targeted drug delivery for targeted drug delivery. https://jns.kashanu.ac.ir/article_111639_02d6414bf60a314c905bbdde41d4bb8c.pdf