Nanostructured Modified Electrode for Electrocatalytic Determination of Epinephrine in the Presence of Acetaminophen

Document Type: Research Paper

Authors

1 Department of Chemistry, Faculty of Science, Yazd University, Yazd, I. R. Iran

2 Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I. R. Iran

10.7508/jns.2011.02.008

Abstract

In this paper, a nanostructured modified electrode was fabricated by incorporating of 2,2′-[1,9-nonanediylbis(nitriloethylidyne)]-bis-hydroquinone (NNH) as a newly synthesized modifier and TiO2 nanoparticles to the carbon paste (MTCPE) and then was used for the electroanalysis of epinephrine (EP). The electrochemical studies were carried out by using cyclic voltammetry, chronoamperometry and differential pulse voltammetry (DPV) techniques. It has been found that the oxidation of EP at the surface of this electrode occurs at a potential about 235 mV less positive than that of an unmodified carbon paste electrode. A dynamic range of 1.0–2000.0 μM, with a detection limit of 0.37 μM for EP, was obtained using DPV. Also, this modified electrode exhibits well separated oxidation peaks for EP and acetaminophen (AC) using DPV.

Keywords


[1] M. Mazloum-Ardakani, M.A. Sheikh-Mohseni, A. Benvidi, Electroanalysis, 23 (2011) 2822–2831.

[2] M. Mazloum-Ardakani, H. Beitollahi, M.A. Sheikh-Mohseni, H. Naeimi, N. Taghavinia, Appl. Catal. A. Gen. 378 (2010) 195–201.

[3] M. Mazloum-Ardakani, H. Beitollahi, M.K. Amini, F. Mirkhalf, B.B.F. Mirjalili, Biosens.Bioelectron. 26 (2011) 2102–2106.

[4] C.B. Jacobs, M.J. Peairs, B.J. Venton, Anal. Chim.Acta 662 (2010) 105–127.

[5] M.Mazloum-Ardakani, M.A. Sheikh-Mohseni, H.Beitollahi, A.Benvidi, H. Naeimi, Chin. Chem.Lett. 21 (2010) 1471–1474.

[6] J. Wang, R.P. Deo, P. Poulin, M. Mangey, J. Am. Chem. Soc. 125 (2003) 14706–14707.

[7] M. Mazloum-Ardakani, A. Talebi, H. Naeimi, M.A. Sheikh-Mohseni, Anal. Methods 3 (2011) 2328–2333.

[8] W.A. Banks, Brain Res. 899 (2001) 209–217.

[9] C.G. Amorim, A.N. Araujo, M.C.B.S.M. Montenegro, Talanta 72 (2007) 1255–1260.

[10] I.A. Macdonald, D.M. Lake, J. Neurosci. Methods 13 (1985) 239–248.

[11] C. Sabbioni, M.A. Saracino, R. Mandrioli, S. Pinzauti, S. Furlanetto, G. Gerra, M.A. Raggi, J.Chromatogr. A 1032 (2004) 65–71.

[12] M.Mazloum-Ardakani, H.Beitollahi, M.K.Amini, B.B.F.Mirjalili, F.Mirkhalf, J.Electroanal. Chem. 651 (2011) 243–249.

[13] H. Beitollahi, M. Mazloum-Ardakani, B. Ganjipour, H. Naeimi, Biosens. Bioelectron. 24 (2008) 362–368.

[14] R.M. De-Carvalho, R.S. Freire, S. Rath, L.T. Kubota, J. Pharm. Biomed.Anal. 34 (2004) 871–878.

[15] B.D. Clayton, Y.N. Stock, Basic pharmacology for nurses,2001, St. Louis: Mosby Inc Harcourt Health Sciences Company.

[16] G. Burgot, F. Auffret, J.L. Burgot, Anal.Chim.Acta 343 (1997) 125–128.

[17] N. Erk, Y. Ozkan, E. Banoglu, S.A. Ozkan, Z.Senturk, J. Pharm. Biomed. Anal. 24 (2001) 469–475.

[18] D.J. Speed, S.J. Dickson, E.R. Cairns, N.D. Kim,J. Anal. Toxicol. 25 (2001) 198–202.

[19] M. Mazloum-Ardakani, H. Beitollahi, M.K. Amini, F. Mirkhalaf, M.Abdollahi-Alibeik, Sens. Actuators B Chem. 151 (2010) 243–249.

[20] M. Mazloum-Ardakani, Z. Taleat, H. Beitollahi, H. Naeimi, J. Iran. Chem. Soc. 7 (2010) 251–259.

[21] M. Mazloum-Ardakani, M.A. Sheikh-Mohseni, H. Beitollahi, A. Benvidi, H. Naeimi, Turk. J. Chem.35 (2011) 573–585.

[22] M. Mazloum-Ardakani, H. Beitollahi, M.K. Amini, F. Mirkhalaf, M. Abdollahi-Alibeik, Anal. Methods3 (2011) 673–677.

[23] M. Mazloum-Ardakani, H. Beitollahi, M.A. Sheikh Mohseni, A. Benvidi, H. Naeimi, M. Nejati-Barzoki, N. Taghavinia, Colloids Surf. B76 (2010) 82–87.

[24] E. Laviron, J. Electroanal. Chem.101 (1979) 19–28.

[25] A.J. Bard, L.R. Faulkner, Electrochemical Methods: Fundamentals and Applications, 2001, Wiley, New York.

[26] Z. Galus, Fundamentals of Electrochemical Analysis, 1976, Ellis Horwood, New York.