Synthesis of Mesoporous Silica and Modified as a Drug Delivery System of Ibuprofen

Document Type: Research Paper

Authors

1 Babol University of Medical Sciences, pramedicine Faculty, Anesthesiology and Operation Department, Babol, Iran

2 Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

10.7508/jns.2016.01.014

Abstract

In this work we synthesized of mesoporous silica nanoparticles and functionalized with 3-aminopropyltriethoxysilane to improve the loading and release of ibuprofen bonded to 3-aminopropyltriethoxysilane. sample were characterized by Fourier transform infrared spectroscopy, Scanning electron microscopy , X-ray diffraction, and ultraviolet-visible. the Fourier transform infrared spectroscopy result demonstrate that organic group were successfully functionalized onto mesoporous silica nanoparticles. Then, we investigate of the adsorption and release of ibuprofen as a drug delivery system in simulated body fluid. The result demonstrates that high adsorption capacity for drug with functionalized sample and slower drug release rate was achieved.

Keywords