Effect of Some Synthetic Parameters on Size and Polydispersity Index of Gelatin Nanoparticles Cross-Linked by CDI/NHS System

Document Type: Research Paper

Authors

1 School of Chemistry, University College of Science, University of Tehran, I.R.Iran

2 Biomaterials Research Center (BRC), University of Tehran, Tehran, I.R.Iran

10.7508/jns.2015.02.008

Abstract

In our previous work, the effect of use of a water soluble CDI/NHS system as nontoxic cross-linking agent on fabrication of gelatin nanoparticles was investigated. In this research, the effect of variation in some synthetic parameters of gelatin nanoparticles cross-linked by CDI/NHS system such as type of gelatin and formulation of cross- linking agent on their size and distribution was examined. The conventional two step desolvation method was used for preparation of gelatin nanoparticles. The morphology, mean size and size distribution of the formed nanoparticles were evaluated and compared with each other. In addition, intrinsic viscosities of all the nanoparticles were measured and compared under different conditions. The results showed that the presence of more NHS and absence of NHS catalyst in CDI/NHS system lead to the large particle size and broad size distribution of nanoparticles that were attributed to the fast and slow cross-linking rate, respectively.

Keywords


[1] H. G. Schwick and K. Heide, Bibliotheca Haematologica, 3 (1969) 111-125.

[2] A. O. Elzoghby, W. M. Samy, N. A. Elgindy, Journal of Controlled Release, 161(2012) 38-49.

[3] J. Xu, F. Gattacceca, M. Amiji, J. Mol. Pharmaceutics. 10 (2013) 2031-2044.

[4] S. K. Nitta and K. Numata, Int. J. Mol. Sci. 14 (2013) 1629-1654. 

[5] J-H. Xu, F-P.Gao, X-F.  Liu, Q.  Zeng, Sh-Sh. Guo, Zh-Y. Tang, X-Zh. Zhao and H. Wang, J. Chem. Commun.49 (2013) 4462-4462.

[6] C. J. Coester, K. Langer, H. V. Brisen, J. Kreuter, J. Microencapsul.17 (2000) 187-193.

[7] M. Mozafari and F. Moztarzadeh, Journal of Colloid and Interface Science, 351 (2010) 442-448.

[8] C.-L. Tseng, K.-C.Yang,  K.-C.Yen, S.Y.-H.Wu, F.-H, Current Nanoscience, 7 (2011) 932-937.

[9] H. Wang, O. Boerman, K. Sariibrahimoglu, Y. Li, J. Jansen, S. Leeuwenburgh, Biomaterials, 33 (2012) 8695-8703.

[10] N. Kuntworbe and R. Al-Kassas, J. AAPS. Pharm. Sci. Tech. 13 (2012) 568-581.

[11]H. Wang, Q. Zou, O. Boerman, A. Nijhuis, J. Jansen, Y. Li, S. Leeuwenburgh, Journal of Controlled Release, 166 (2013) 172-181.

[12]E. J. Lee, S. Ahmad Khan, J. K. Park, K-H. Lim, J. Bioprocess Biosyst Eng. 35 (2012) 297–307.

[13] S. Ahmad Khan, M. Schneider, J. Macromol. Biosci. 13 (2013) 455–463.

[14] R. C. Oppenheim and N. F. Stewart, Drug Dev. Ind. Pharm.5 (1979) 563-571.

[15] E. Leo, M. A. Vandelli, R. Cameroni and F. Forni, Int.J. Pharmaceut.155 (1997) 75-82.

[16] K. W. Leong, H. Q. Mao, V. L. Truong, K. Roy, S. M. Walsh and J. T. August, J.Controlled Release,53 (1998) 183-189.

[17] B. Rossler, J. Kreuter, D. Scherer,Journal of Microencapsulation, 12 (1995) 49-57.

[18] C.-P. Zhang, L .Hu, Y.-P.Luo, W. Deng, X. Gao, Y.-X. Qiu, D.-J  Shen, Fuhe Cailiao Xuebao /Acta Materiae Compositae Sinica, 19 (2002) 59-64 .

[19] M. G. Cascone, L. Lazzeri, C. Carmignani and Z. Zhu, J. Mater. Sci.: Mater.Med.13 (2002) 523-526 .

[20] A. K. Bajpai and J. Chouby, J. Mater. Sci.: Mater. Med.17 (2006) 345-358.

[21] J. Kwon Oh, R. Drumright, D. J. Siegwart, K. Matyjaszewski, J. Prog.Polym. Sci.33 (2008) 448–477.

[22] A. Ethirajan, K. Schoeller, A. Musyanovych, U. Ziener and K. Landfester,Biomacromolecules, 9 (2008) 2383-2389.

[23]A. Ethirajan and Katharina Landfester, J.Chem. Eur. 16 (2010) 9398-9412.

[24] N. TaheriQazvini and S. Zinatloo, J. Mater. Sci: Mater. Med.22 (2011) 63-69.

[25] W. M. Kulicke and C. Clasen, Viscosometry of Polymers and Polyelectrolytes.Speringer-Verlag, Berlin (2004).

[26] C. Vathier and K. Bouchemal, Pharmaceut. Res.26 (2009) 1025-1058.

[27] A. J. Kuijpers, G. H. M. Engbers, J. Feijen, S. C. De Smedt, T. K. L. Meyvis, J.Demeester, J. Krijgsveld, S. A. J. Zaat and J. Dankert, Macromolecules,32(1999) 3325-3333.

[28] R. Timkovicz, Anal. Biochem.79 (1977) 135-143.

[29] H. Yamakawa, Macromolecules,34 (1961) 1360-1372.

[30] A. Gupta, B. Mohanty and H. B. Bohidar, Biomacromolecules, 6 (2005) 1623-1627.